Discover the physiological phenomena of living cells at nanoscale
As a life scientist, you want to see how biological materials look like at nanoscale resolution and how soft they are in liquid and buffer conditions. Park NX12 enables that with its innovative in-liquid imaging Scanning Ion Conductance Microscopy (SICM) and its highly acclaimed Atomic Force Microscopy (AFM) technology.
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More powerful physiological study solutions
Park NX12 is a powerful 3-in-1 bio-research tool that uniquely combines SICM with AFM and an inverted optical microscope (IOM) on the same platform. The modular design of the Park NX12 allows researchers to easily switch between its SICM and AFM capabilities. Designed for non-invasive in-liquid imaging, Park NX12 is the ideal tool for studying biological materials under physiological conditions. It combines the bio-mechanical property measurement capability of the AFM and nano imaging of the SICM in liquid, and the optical viewing of the IOM.
Easy to use, even for entry level researchers
Park NX12 has a user-friendly design and automated imaging software for SICM, so you won’t have to spend so much time for in-liquid imaging. The basic setup for operation can be learned through a simple training course in only a few hours. This allows you to quickly shift your time to conducting more advanced research for your subject.
Physiological Morphology Imaging for Biological Research Laboratories
Scanning Ion Conductance Microscopy (SICM)
- In-liquid imaging with ease
- Delicate membrane morphology imaging at cellular and sub-cellular level
- Biological tissue imaging in three-dimensional (3D) structure
Atomic Force Microscope (AFM)
- High resolution bio-imaging for single molecule with True Non-Contact™ Mode
- Force-distance (FD) spectroscopy for mechanical property characterization of various bio-materials
- Accurate FD spectroscopy control with leading low noise Z detector
- Force volume imaging
Live Cell Chamber
- Optimal temperature, pH, humidity control to maintain viable bio-activity
Reliable and Repeatable Nano Bio-imaging for Better Experimental Verification
- Non-invasive SICM to preserve naïve morphological information of soft bio-materials
- Excellent imaging repeatability in automatically programmed and running software
- Accurate height/depth analysis from 3D structure measurements
Full Integration with Inverted Optical Microscope for high productivity
- Bright field and phase contrast for easier sample finding
- Access to full range of objective lenses up to 100x magnification
- Integration with confocal and fluorescence microscopy
- Advanced image overlay functions
Versatility and practicality: imaging solutions for life science from Park Systems
Tissue Imaging
Article: Biological imaging in liquid with SICMPaper: Scanning ion conductance microscopy for imaging biological samples in liquid
Single Cell Imaging
Article: SICM: non-contact imaging and eletrophysiologyPaper: Biophysical applications of SICM
Bio-mechanical Analysis
Article: Park PinPoint mode for cell biologyPaper: Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds
Application notes
- Targeted patch clamping on cardiomyosite
- Live cell volume measurement of SICM
- PinPoint mode for cell biology
- Analyze cell with Park nano-microscopy